Software features: Interactive tutorials, maveDB heatmaps, feature details pop up in window, "Download > All track data", right-click on transcript + jump-to-exon/jump-to-codon, change color on RefSeq track, new tooltips, ENSTxxx in HGVS, one BLAT track per query, gear icon next to tracks
New human annotation tracks: Llong read RNAs from Gencode and ENCODE, variants in publications: pubTator / VarChat / Avada / Varaico, panelApp AU, variant impact scores: mutScore/M-CAP/Bayes-Del/AlphaMissense, PFAM on the Gencode transcripts, gnomAD 4 and gnomAD pEXT, Pan-genome tracks, Pseudogene parents, NCBI Orthologs, Denovo-db, Mitomap, Splice variant impact scores AbSplice/spliceAI/spliceVarDb, Civic Cancer Variants, Decipher Population CNVs, Genome-in-a-bottle problematic regions, CADD 1.7 update, NumTS hg38, ENIGMA VCEPs, dosage Sensitivity, deprecated RefSeq transcripts, eMerge Polygenic Risk Scores, COSMIC.
Non-human genomes: 20,000 more genomes with basic annotation tracks.
Track hubs and API: bedMethyl format support, updated .hic version, bigBed/bigGenePred "decorators", bigDbSnp/bigMaf/bigChain in the API